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Tandospirone citrate (SM-3997 citrate) 是一种选择性5-HT1A 受体激动剂,Ki 为27 nM。
Tandospirone citrate (SM-3997 citrate) 是一种选择性5-HT1A 受体激动剂,Ki 为27 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 195 | 现货 | |
5 mg | ¥ 446 | 现货 | |
10 mg | ¥ 693 | 现货 | |
25 mg | ¥ 1,390 | 现货 | |
50 mg | ¥ 2,230 | 现货 | |
100 mg | ¥ 3,210 | 现货 | |
500 mg | ¥ 7,430 | 现货 |
产品描述 | Tandospirone citrate (SM-3997 citrate) is a potent and selective 5-HT1A receptor partial agonist (Ki : 27 nM) |
靶点活性 | 5-HT1A:27 nM(ki) |
体内活性 | 在临床试验中, 与安慰剂相比, 使用tandospirone治疗组在第1、2、4周时腹部总评分的改善显著更大。特别是在第4周, tandospirone组在上腹部疼痛(P=0.02)和不适(P=0.002)方面的改善显著更为明显。此外, 在第3(P=0.017)和第4周(P=0.0016), 活性治疗组的应答者比例显著高于对照组。两个研究组在STAI得分上(P<0.0001)以及SF-8的大部分问题上(P=0.04)均报告了显著改善。研究中没有报告严重不良事件, 两组的发生率相似[1]。 |
细胞实验 | In this double-blind, placebo-controlled, multicenter study, FD patients were randomized to treatment with 10 mg t.i.d. tandospirone citrate or to placebo for 4 weeks. The primary end point was change in abdominal symptom scores. The difference in the proportion of responders (a total abdominal symptom score of 0 or 1) was also assessed. The quality-of-life questionnaire, the SF-8, and a psychological test questionnaire, the State-Trait Anxiety Inventory (STAI), were completed at baseline and at weekly intervals[1] |
别名 | 坦度螺酮柠檬酸盐, 枸橼酸坦度螺酮, SM-3997 citrate |
分子量 | 575.61 |
分子式 | C27H37N5O9 |
CAS No. | 112457-95-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: 10.4 mg/mL (18.07 mM), Sonication is recommended. DMSO: 50 mg/mL (86.86 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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